浙江工商大学, 管理工程与电子商务学院, 讲师

致力于环境样品监测、分析化学、有机化学反应机理理论计算等研究，具备多学科交叉基础。1）熟练掌握环境各介质中化合物的前处理过程以及气相（HPLC）/液相色谱（GC）、光谱（ECD/UV/Raman）以及质谱（MS）等仪器的操作测量过程；2）掌握量子化学理论计算，基于密度泛函理论和分子对接技术，探究生物酶（细胞色素P450）代谢环境有机污染物的反应机理及毒性差异；3）熟练使用数据分析（Spss/Origin等）软件，具备化学计量学数据分析校正处理技能，利用快速检测技术协同大数据驱动，聚焦食品和药品的质量安全问题。

(1)    Guo F J, Chai L H, Zhang S B, Yu H Y, Liu W P, Kepp K P, Ji L*. Computational biotransformation profile of emerging phenolic pollutants by Cytochromes P450: Phenol-coupling mechanism. Environmental Science & Technology, 2020, 54(5): 2902-2912.

(2)    Guo F J, Yin S S, Wang H Y, Zhang J Y, Liu Y X, Aamir M, Liu W P*. Polychlorinated biphenyls (PCBs) in the Colostrum Samples from the Yangtze River Region: Exposure Profile and Risk Assessment[J]. Environmental Pollution, 2021, 285:117253.

(3)    Guo F J, Wang Z Y, Zhao L, Liu W P*. A proposed method of enantioselectivity analysis for residual chiral PCBs in gas chromatography. Chemosphere, 2019, 229: 401-408

(4)    Guo F J, Tang Q Z, Xie J Q, Zhao L, Liu K, Liu W P*. Enantioseparation and identification for the rationalization of the environmental impact of 4 polychlorinated biphenyls. Chirality, 2018, 30:475-483

(5)    Guo F J, Zhang J*, Wang C C. Enantioselectivity in environmental safety and metabolism of typical chiral organic pollutants. Current Protein & Peptide Science, 2016, 18:4-9

(6)    Yin S S, Guo F J, Muhammad A, Liu Y X, Tang ML, Liu W P*. Multicenter biomonitoring of polybrominated diphenyl ethers (PBDEs) in colostrum from China: Body burden profile and risk assessment. Environmental Research, 2019, 179:108828

(7)    Aamir M, Yin S S, Guo F J, Liu K, Liu W P*. Congener-specific mother-fetus distribution, placental retention, and transport of C_(10-13) and C_(14-17) chlorinated paraffins in pregnant women[J]. Environmental Science & Technology, 2019, 53(19).

(8)    Yin S S, Zhang J Y, Guo F J, Zhao L, Poma G, Covaci A, Liu W P*. Transplacental transfer of organochlorine pesticides: Concentration ratio and chiral properties. Environment International, 2019, 130:104939

(9)    Zhao L, Xie J Q, Guo F J, Liu K*. Enantioseparation of napropamide by supercritical fluid chromatography: Effects of the chromatographic conditions and separation mechanism. Chirality, 2018, 30:661-669

(10)Zhang, H., Song, R., Guo, F., Chai, L., Wang, W., Zeng, J., et al. Using physical organic chemistry knowledge to predict unusual metabolites of synthetic phenolic antioxidants by cytochrome p450. Chemical research in toxicology, 2022, (5), 35.

(11)Chai, L., Zhang, H., Guo, F., Song, R., Yu, H., Ji, L. Computational investigation of the bisphenolic drug metabolism by cytochrome p450: what factors favor intramolecular phenol coupling. Chemical research in toxicology, 2022, (3), 35.

(12)Dong, Y. Yin, S. Zhang, J. Guo, F., Aamir, M., Liu, S, et al. Exposure patterns, chemical structural signatures, and health risks of pesticides in breast milk: a multicenter study in china. Science of the Total Environment, 2022, 830.

(13)Xie J Q, Zhao L, Liu K, Guo F J, Chen Z W, Liu W P*. Enantiomeric characterization of herbicide lactofen: Enantioseparation, absolute configuration assignment and enantioselective activity and toxicity. Chemosphere, 2018, 193:351-357

(14)Xie J Q, Zhao L, Liu K, Guo F J, Gao L D, Liu W P*. Activity, toxicity, molecular docking, and environmental effects of three imidazolinone herbicides enantiomers. Science of the Total Environment, 2018, 622:594-602

(1)2023.01-2025.12：P450酶介导二元混合暴露代谢抑制机理：以酚类抗氧化活性剂和有机磷农药为例（国家自然科学基金青年项目22206170，主持）；

(2)2018.01-2020.12：近红外光响应的光催化降解有机污染物体系的设计制备及其催化应用研究（国家自然科学基金青年项目41703083，参与）；

(3)2018.01-2020.12：维生素B12催化典型卤代有机污染物还原脱卤反应机理的理论研究（国家自然科学基金面上项目 21677125，参与）；

(4)2015.01-2019.12：手性污染物的分离、表征及稳定性研究系统（国家自然科学基金重大仪器专项项目21427815，参与）；